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	76. 7262 Accesses	Review Autism genetics: searching for specificity and convergence Jamee M Berg, Daniel H Geschwind Genome Biology 2012, 13:247 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Daniel Geschwind and Jamee Berg review the genes associated with autism spectrum disorders: how might their functions relate to one another?
	77. 7259 Accesses	Research Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms Fredrik Barrenäs, Sreenivas Chavali, Alexessander Alves, Lachlan Coin, Marjo-Riitta Jarvelin, Rebecka Jörnsten, Michael A Langston, Adaikalavan Ramasamy, Gary Rogers, Hui Wang, Mikael Benson Genome Biology 2012, 13:R46 (15 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gene network analysis can predict novel disease-associated genes and finds significant overlap between phenotypically disparate complex diseases
	78. 7237 Accesses	Research Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis Fei Gao, Xiaolei Liu, Xiu-Ping Wu, Xue-Lin Wang, Desheng Gong, Hanlin Lu, Yudong Xia, Yanxia Song, Junwen Wang, Jing Du, Siyang Liu, Xu Han, Yizhi Tang, Huanming Yang, Qi Jin, Xiuqing Zhang, Mingyuan Liu Genome Biology 2012, 13:R100 (17 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The discovery of DNA methylation in the parasitic worm Trichinella spiralis, a human pathogen, challenges the prevailing dogma of nematode epigenetics
	79. 7288 Accesses	Editorial Raymond Gosling: the man who crystallized genes Naomi Attar Genome Biology 2013, 14:402 (25 April 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary "The most wonderful thing!" - Genome Biology meets Raymond Gosling, a key player in the discovery of the double helix
	80. 7178 Accesses	Research Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development Marilyn B Renfree, Anthony T Papenfuss, Janine E Deakin, James Lindsay, Thomas Heider, Katherine Belov, Willem Rens, Paul D Waters, Elizabeth A Pharo, Geoff Shaw, Emily SW Wong, Christophe M Lefèvre, Kevin R Nicholas, Yoko Kuroki, Matthew J Wakefield, Kyall R Zenger, Chenwei Wang, Malcolm Ferguson-Smith, Frank W Nicholas, Danielle Hickford, Hongshi Yu, Kirsty R Short, Hannah V Siddle, Stephen R Frankenberg, Keng Chew, Brandon R Menzies, Jessica M Stringer, Shunsuke Suzuki, Timothy A Hore, Margaret L Delbridge et al. Genome Biology 2011, 12:R81 (19 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The tammar wallaby genome and transcriptome sequences yield insights into many aspects of mammalian biology
	81. 7178 Accesses	Method A novel and universal method for microRNA RT-qPCR data normalization Pieter Mestdagh, Pieter Van Vlierberghe, An De Weer, Daniel Muth, Frank Westermann, Frank Speleman, Jo Vandesompele Genome Biology 2009, 10:R64 (16 June 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The mean expression value: a new method for accurate and reliable normalization of microRNA expression data from RT-qPCR experiments.
	82. 7100 Accesses	Software Searching for SNPs with cloud computing Ben Langmead, Michael C Schatz, Jimmy Lin, Mihai Pop, Steven L Salzberg Genome Biology 2009, 10:R134 (20 November 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Novel software utilizing cloud computing technology to cost-effectively align and map SNPs from a human genome in three.
	83. 6995 Accesses	Research Inferring the kinetics of stochastic gene expression from single-cell RNA-sequencing data Jong Kim, John C Marioni Genome Biology 2013, 14:R7 (28 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new framework for modeling stochastic gene expression in single cells yields insights into the regulatory role of histone modifications
	84. 6939 Accesses	Method Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions Yoichiro Sugimoto, Julian König, Shobbir Hussain, Blaž Zupan, Tomaž Curk, Michaela Frye, Jernej Ule Genome Biology 2012, 13:R67 (3 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The CLIP and iCLIP methods are compared for their utility in determining RNA binding protein binding sites
	85. 6915 Accesses	Research Microbiome dynamics of human epidermis following skin barrier disruption Patrick LJM Zeeuwen, Jos Boekhorst, Ellen H van den Bogaard, Heleen D de Koning, Peter MC van de Kerkhof, Delphine M Saulnier, Iris I van Swam, Sacha AFT van Hijum, Michiel Kleerebezem, Joost Schalkwijk, Harro M Timmerman Genome Biology 2012, 13:R101 (15 November 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of the microbiota of the surface and deeper layers of skin, and how it changes following skin barrier disruption
	86. 6857 Accesses	Method SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips Jovana Maksimovic, Lavinia Gordon, Alicia Oshlack Genome Biology 2012, 13:R44 (15 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A method for normalizing the Illumina 450k methylation array data, allowing analysis of the genome-wide methylation status of the human genome
	87. 6820 Accesses	Method BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions Kasper D Hansen, Benjamin Langmead, Rafael A Irizarry Genome Biology 2012, 13:R83 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An alignment, quality control and analysis pipeline for bisulfite sequencing data
	88. 6811 Accesses	Research highlight A CRISPR way to engineer the human genome Sivaprakash Ramalingam, Narayana Annaluru, Srinivasan Chandrasegaran Genome Biology 2013, 14:107 (26 February 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Srinivasan Chandrasegaran and colleagues explain how recent advances in mammalian genome engineering exploit the natural properties of the bacterial CRISPR system
	89. 6778 Accesses	Comment A modest proposal for an outreach section in scientific publications Chris Gunter, Anne Osterrieder Genome Biology 2012, 13:168 (31 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary By Chris Gunter and Anne Osterrieder
	90. 6783 Accesses	Comment After the gold rush Neil Hall Genome Biology 2013, 14:115 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Neil Hall wonders whether genomics is ready for a plateau in sequencing costs
	91. 6736 Accesses	Editorial What can epigenomics do for you? Alexander Meissner Genome Biology 2012, 13:420 (23 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Alexander Meissner asks not what you can do for epigenomics, but what epigenomics can do for you
	92. 6646 Accesses	Opinion Categorization of humans in biomedical research: genes, race and disease Neil Risch, Esteban Burchard, Elad Ziv, Hua Tang Genome Biology 2002, 3:comment2007-comment2007.12 (1 July 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A debate has arisen regarding the validity of racial/ethnic categories for biomedical and genetic research. An epidemiologic perspective on the issue of human categorization in biomedical and genetic research strongly supports the continued use of self-identified race and ethnicity.
	93. 6636 Accesses	Research Apple miRNAs and tasiRNAs with novel regulatory networks Rui Xia, Hong Zhu, Yong-qiang An, Eric P Beers, Zongrang Liu Genome Biology 2012, 13:R47 (15 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comprehensive analysis of short regulatory RNAs including, miRNAs, siRNAs and tasiRNAs in the apple tree Malus domestica Golden Delicious
	94. 6594 Accesses	Review Computational and statistical approaches to analyzing variants identified by exome sequencing Nathan O Stitziel, Adam Kiezun, Shamil Sunyaev Genome Biology 2011, 12:227 (14 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Many computational and statistical methods are now available to narrow down causal variants in exome sequencing data, for both Mendelian and complex diseases
	95. 6552 Accesses	Research High levels of RNA-editing site conservation amongst 15 laboratory mouse strains Petr Danecek, Christoffer Nellåker, Rebecca E McIntyre, Jorge E Buendia-Buendia, Suzannah Bumpstead, Chris P Ponting, Jonathan Flint, Richard Durbin, Thomas M Keane, David J Adams Genome Biology 2012, 13:r26 (23 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An extensive, genome-wide analysis of RNA editing in the brain transcriptomes of 15 mouse strains
	96. 6531 Accesses	Research The genome of the polar eukaryotic microalga Coccomyxa subellipsoidea reveals traits of cold adaptation Guillaume Blanc, Irina Agarkova, Jane Grimwood, Alan Kuo, Andrew Brueggeman, David D Dunigan, James Gurnon, Istvan Ladunga, Erika Lindquist, Susan Lucas, Jasmyn Pangilinan, Thomas Pröschold, Asaf Salamov, Jeremy Schmutz, Donald Weeks, Takashi Yamada, Alexandre Lomsadze, Mark Borodovsky, Jean-Michel Claverie, Igor V Grigoriev, James L Van Etten Genome Biology 2012, 13:R39 (25 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The first genome of a polar eukaryotic microorganism, an alga called Coccomyxa subellipsoidea C-169, reveals universal strategies for cold adaptation
	97. 6521 Accesses	Research highlight We are what we eat: how the diet of infants affects their gut microbiome Mihai Pop Genome Biology 2012, 13:152 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We are what we eat: Mihai Pop highlights our Research article investigating the impact of diet on an infant's gut
	98. 6480 Accesses	Research highlight The aging epigenome: DNA methylation from the cradle to the grave Marc Winnefeld, Frank Lyko Genome Biology 2012, 13:165 (30 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Frank Lyko and Marc Winnefeld highlight a new survey of age-related epigenetic changes in newborn and centenarian methylomes
	99. 6411 Accesses	Software RedeR: R/Bioconductor package for representing modular structures, nested networks and multiple levels of hierarchical associations Mauro AA Castro, Xin Wang, Michael NC Fletcher, Kerstin B Meyer, Florian Markowetz Genome Biology 2012, 13:R29 (24 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A method for visualizing complex, large-scale networks that combines R/Bioconductor with Java, and allows the incorporation of plug-ins
	100. 6396 Accesses	Method Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling Patrick Boyle, Kendell Clement, Hongcang Gu, Zachary D Smith, Michael Ziller, Jennifer L Fostel, Laurie Holmes, Jim Meldrim, Fontina Kelley, Andreas Gnirke, Alexander Meissner Genome Biology 2012, 13:R92 (3 October 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A protocol for gel-free multiplexed reduced representation bisulfite sequencing increases the throughput and reduces the cost of large-scale DNA methylation profiling