Genome Biology aims to provide review material that readers need in order to assess and evaluate progress in genomic and post-genomic research. Protein family reviews aim to provide a standardized set of information about families of structurally and functionally related proteins. Each protein family review includes information on gene and protein structure, evolution, localization and function, and is intended as a quick reference source for readers unfamiliar with the family. Protein family reviews are usually commissioned, with the editors aiming to ensure coverage of all relevant areas of biology and genomics but suggestions of protein family reviews are welcome.

Protein family review   

(26 February 2008)

RNA-guided gene silencing is mediated by proteins of the Argonaute family

Protein family review   

(31 January 2008)

The Groucho family of co-repressor proteins are essential for development and may also have a role in some human cancers.

Protein family review   

(28 December 2007)

The reticulon family is a diverse group of proteins that mostly localize to the endoplasmic reticulum and may be important in neurodegenerative diseases.

Protein family review   

(26 September 2007)

An overview of the vertebrate members of a diverse family of basic DNA-binding proteins that are synthesized in the late-stage spermatids of many animals and plants and condense the spermatid genome into a genetically inactive state.

Protein family review   

(2 July 2007)

The eukaryotic calpains are a family of calcium-dependent papain-like proteases and their non-enzymatic relatives whose varied physiological functions are beginning to be fully explored.

Protein family review   

(1 June 2007)

An overview of a family of cell-surface adhesion and signaling receptors that mediate cell-cell adhesion and cell-extracellular matrix adhesion.

Protein family review   

(15 March 2007)

An overview of the large and functionally diverse RBR protein family that mediates protein-protein interactions of various kinds in development and disease.