Genome Biology aims to provide review material that readers need in order to assess and evaluate progress in genomic and post-genomic research. Protein family reviews aim to provide a standardized set of information about families of structurally and functionally related proteins. Each protein family review includes information on gene and protein structure, evolution, localization and function, and is intended as a quick reference source for readers unfamiliar with the family. Protein family reviews are usually commissioned, with the editors aiming to ensure coverage of all relevant areas of biology and genomics but suggestions of protein family reviews are welcome.

Protein family review   

(15 June 2009)

A review of the cytoskeleton-organizing WASP and WAVE family proteins.

Protein family review   

(17 March 2009)

The proteins of the origin recognition complex are found throughout all eukaryotes and have roles beyond that of DNA replication.

Protein family review   

(19 November 2008)

Hedgehog proteins, which are important in developmental signaling, have been joined by other newly discovered proteins from throughout the eukaryotes in the Hint-domain-containing group of proteins.

Protein family review   

(29 July 2008)

Tektins are insoluble a-helical proteins essential for the construction of cilia and flagella and are found throughout the eukaryotes apart from higher plants.

Protein family review   

(17 June 2008)

An overview of the AID/APOBEC family of cytidine deaminases, enzymes that can mutate RNA and DNA.

Protein family review    

(22 May 2008)

The glypican family of cell-surface heparan sulfate proteoglycans modulate the actions of many developmentally important signal proteins.

Protein family review    

(26 February 2008)

RNA-guided gene silencing is mediated by proteins of the Argonaute family

Protein family review    

(31 January 2008)

The Groucho family of co-repressor proteins are essential for development and may also have a role in some human cancers.