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Genome Biology aims to provide review material that readers need in order to assess and evaluate progress in genomic and post-genomic research. Protein family reviews aim to provide a standardized set of information about families of structurally and functionally related proteins. Each protein family review includes information on gene and protein structure, evolution, localization and function, and is intended as a quick reference source for readers unfamiliar with the family. Protein family reviews are usually commissioned, with the editors aiming to ensure coverage of all relevant areas of biology and genomics but suggestions of protein family reviews are welcome.
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Protein family reviews

The PIN-FORMED (PIN) protein family of auxin transporters

Protein family review   
Pavel Keek, Petr Skpa, Jií Libus, Satoshi Naramoto, Ricardo Tejos, Jií Friml, Eva Zaímalová
(29 December 2009)

A review of the PIN auxin-efflux transporters, which have important roles in plant development.

[Abstract] [Full text] [PDF]

The WUS homeobox-containing (WOX) protein family

Protein family review   
Eric van der Graaff, Thomas Laux, Stefan A Rensing
(29 December 2009)

The plant-specific WOX family of homeobox proteins have key functions in plant development.

[Abstract] [Full text] [PDF]

The SR protein family

Protein family review   
Peter J Shepard, Klemens J Hertel
(27 October 2009)

The SR proteins are not only involved in pre-mRNA splicing but in mRNA export and the initiation of translation.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

The netrin protein family

Protein family review   
Sathyanath Rajasekharan, Timothy E Kennedy
(29 September 2009)

The netrins are a family of extracellular proteins that direct cell and axon migration during embryogenesis.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

The claudins

Protein family review   
Madhu Lal-Nag, Patrice J Morin
(26 August 2009)

Claudins are crucial components of tight junctions and are important in regulating permeability and maintaining cell polarity in cell sheets.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

The WASP and WAVE family proteins

Protein family review   
Shusaku Kurisu, Tadaomi Takenawa
(15 June 2009)

A review of the cytoskeleton-organizing WASP and WAVE family proteins.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

The origin recognition complex protein family

Protein family review   
Bernard P Duncker, Igor N Chesnokov, Brendan J McConkey
(17 March 2009)

The proteins of the origin recognition complex are found throughout all eukaryotes and have roles beyond that of DNA replication.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

The Hedgehog protein family

Protein family review    
Thomas R Bürglin
(19 November 2008)

Hedgehog proteins, which are important in developmental signaling, have been joined by other newly discovered proteins from throughout the eukaryotes in the Hint-domain-containing group of proteins.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Additional protein family review articles from Genome Biology. For a complete listing choose 'list all' from the menu to the left.





























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