CTL granules: evolution of vesicles essential for combating virus infections.
Trapani JA, Sutton VR, Smyth MJ.
Austin Research Institute, Studley Road, Heidelberg 3084, Australia. j.trapani@ari.unimelb.edu.au
Viral strategies for escaping apoptosis have co-evolved with the immune system, resulting in a complex balance of pro- and anti-apoptotic forces in virus-infected cells under attack by cytotoxic T lymphocytes (CTLs). Here, Joseph Trapani and colleagues argue that CTL cytolytic granules are the principal apoptotic means of eliminating viruses and possess multiple independent mechanisms to counter the viral anti-apoptotic machinery.
Publication Types:
PMID: 10431154 [PubMed - indexed for MEDLINE]