Sequence-specific DNA recognition by polyamides.
Dervan PB, Bürli RW.
Department of Chemistry, California Institute of Technology, Pasadena, CA 91125, USA. dervan@cco.caltech.edu.
Sequence-specific DNA-binding small molecules that can permeate cells could potentially regulate transcription of specific genes. Simple pairing rules for the minor groove of the double helix have been developed that allow the design of ligands for predetermined DNA sequences. Some of these polyamides have been shown to inhibit specific gene expression in mammalian cell culture.
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PMID: 10600731 [PubMed - indexed for MEDLINE]