Recent advances in structure-based rational drug design.
Gane PJ, Dean PM.
De Novo Pharmaceuticals Ltd., Cambridge, UK. paul.gane@ddg.phar.cam.ac.uk
Two approaches to structure-based drug design, that is, the docking of known compounds into a target protein and molecular assembly in situ, are seen to be merging technologies. The need for structural information about drug-protein complexes is now fundamental for drug discovery.
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PMID: 10981625 [PubMed - indexed for MEDLINE]