Your browser version may not work well with NCBI's Web applications. More information here...
1: Science. 2001 Nov 23;294(5547):1719-23.
Related Articles, Links
Click here to read Click here to read
Comment in:
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21.

Patil N, Berno AJ, Hinds DA, Barrett WA, Doshi JM, Hacker CR, Kautzer CR, Lee DH, Marjoribanks C, McDonough DP, Nguyen BT, Norris MC, Sheehan JB, Shen N, Stern D, Stokowski RP, Thomas DJ, Trulson MO, Vyas KR, Frazer KA, Fodor SP, Cox DR.

Perlegen Sciences, Inc., 2021 Stierlin Court, Mountain View, CA 94043, USA.

Global patterns of human DNA sequence variation (haplotypes) defined by common single nucleotide polymorphisms (SNPs) have important implications for identifying disease associations and human traits. We have used high-density oligonucleotide arrays, in combination with somatic cell genetics, to identify a large fraction of all common human chromosome 21 SNPs and to directly observe the haplotype structure defined by these SNPs. This structure reveals blocks of limited haplotype diversity in which more than 80% of a global human sample can typically be characterized by only three common haplotypes.

PMID: 11721056 [PubMed - indexed for MEDLINE]