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1: Cell. 2002 Apr 19;109(2):217-28.
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Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons.

Soussi-Yanicostas N, de Castro F, Julliard AK, Perfettini I, Chédotal A, Petit C.

Unité de Génétique des Déficits Sensoriels, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1968, Institut Pasteur, 25 rue du Dr Roux, F-75724 Paris cedex 15, France. nyani@pasteur.fr

The physiological role of anosmin-1, defective in the X chromosome-linked form of Kallmann syndrome, is not yet known. Here, we show that anti-anosmin-1 antibodies block the formation of the collateral branches of rat olfactory bulb output neurons (mitral and tufted cells) in organotypic cultures. Moreover, anosmin-1 greatly enhances axonal branching of these dissociated neurons in culture. In addition, coculture experiments with either piriform cortex or anosmin-1-producing CHO cells demonstrate that anosmin-1 is a chemoattractant for the axons of these neurons, suggesting that this protein, which is expressed in the piriform cortex, attracts their collateral branches in vivo. We conclude that anosmin-1 has a dual branch-promoting and guidance activity, which plays an essential role in the patterning of mitral and tufted cell axon collaterals to the olfactory cortex.

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PMID: 12007408 [PubMed - indexed for MEDLINE]