A mark in the core: silence no more!
Varga-Weisz PD, Dalgaard JZ.
Marie Curie Research Institute, The Chart, Oxted RH8 0TL, Surrey, UK.
The histone modification repertoire has recently been expanded. Dot1p is a new type of methyltransferase that methylates lysine 79 in the histone H3 core only in its nucleosomal context and has a possible role in marking open chromatin regions.
PMID: 12086611 [PubMed - indexed for MEDLINE]