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1: Cell. 2003 May 2;113(3):395-404.
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Program-specific distribution of a transcription factor dependent on partner transcription factor and MAPK signaling.

Zeitlinger J, Simon I, Harbison CT, Hannett NM, Volkert TL, Fink GR, Young RA.

Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. zeitlinger@wi.mit.edu

Specialized gene expression programs are induced by signaling pathways that act on transcription factors. Whether these transcription factors can function in multiple developmental programs through a global switch in promoter selection is not known. We have used genome-wide location analysis to show that the yeast Ste12 transcription factor, which regulates mating and filamentous growth, is bound to distinct program-specific target genes dependent on the developmental condition. This condition-dependent distribution of Ste12 requires concurrent binding of the transcription factor Tec1 during filamentation and is differentially regulated by the MAP kinases Fus3 and Kss1. Program-specific distribution across the genome may be a general mechanism by which transcription factors regulate distinct gene expression programs in response to signaling.

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PMID: 12732146 [PubMed - indexed for MEDLINE]