Your browser version may not work well with NCBI's Web applications. More information here...
1: Nat Genet. 2003 Nov;35(3):215-7. Epub 2003 Oct 5.
Related Articles, Links
Click here to read Click here to read
Erratum in:
  • Nat Genet. 2003 Nov;35(3):287.

Dicer is essential for mouse development.

Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ.

Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

Publication Types:
PMID: 14528307 [PubMed - indexed for MEDLINE]