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1: Nature. 2004 Sep 16;431(7006):356-63.
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RNA silencing in plants.

Baulcombe D.

The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK. david.baulcombe@sainsbury-laboratory.ac.uk

There are at least three RNA silencing pathways for silencing specific genes in plants. In these pathways, silencing signals can be amplified and transmitted between cells, and may even be self-regulated by feedback mechanisms. Diverse biological roles of these pathways have been established, including defence against viruses, regulation of gene expression and the condensation of chromatin into heterochromatin. We are now in a good position to investigate the full extent of this functional diversity in genetic and epigenetic mechanisms of genome control.

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PMID: 15372043 [PubMed - indexed for MEDLINE]