Your browser version may not work well with NCBI's Web applications. More information here...
1: Genome Biol. 2005;6(2):R20. Epub 2005 Feb 1.
Related Articles, Links
Click here to read Click here to read
Genomic analysis of early murine mammary gland development using novel probe-level algorithms.

Master SR, Stoddard AJ, Bailey LC, Pan TC, Dugan KD, Chodosh LA.

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA. srmaster@mail.med.upenn.edu

We describe a novel algorithm (ChipStat) for detecting gene-expression changes utilizing probe-level comparisons of replicate Affymetrix oligonucleotide microarray data. A combined detection approach is shown to yield greater sensitivity than a number of widely used methodologies including SAM, dChip and logit-T. Using this approach, we identify alterations in functional pathways during murine neonatal-pubertal mammary development that include the coordinate upregulation of major urinary proteins and the downregulation of loci exhibiting reciprocal imprinting.

Publication Types:
PMID: 15693949 [PubMed - indexed for MEDLINE]

PMCID: PMC551540