Boosting with stumps for predicting transcription start sites.
Zhao X, Xuan Z, Zhang MQ.
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA. zhaox@cshl.edu
Promoter prediction is a difficult but important problem in gene finding, and it is critical for elucidating the regulation of gene expression. We introduce a new promoter prediction program, CoreBoost, which applies a boosting technique with stumps to select important small-scale as well as large-scale features. CoreBoost improves greatly on locating transcription start sites. We also demonstrate that by further utilizing some tissue-specific information, better accuracy can be achieved.
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PMID: 17274821 [PubMed - indexed for MEDLINE]PMCID: PMC1852414