Determining promoter location based on DNA structure first-principles calculations.
Goñi JR, Pérez A, Torrents D, Orozco M.
Institute for Research in Biomedicine, Parc Científic de Barcelona, Josep Samitier, Barcelona 08028, Spain.
A new method for the prediction of promoter regions based on atomic molecular dynamics simulations of small oligonucleotides has been developed. The method works independently of gene structure conservation and orthology and of the presence of detectable sequence features. Results obtained with our method confirm the existence of a hidden physical code that modulates genome expression.
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PMID: 18072969 [PubMed - indexed for MEDLINE]PMCID: PMC2246265