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1: Science. 1971 Jan 22;171(968):294-7.
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Increasing the multiplicity of ribosomal RNA genes in Drosophila melanogaster.

Tartof KD.

In wild-type Drosophila melanogaster females there are about 250 ribosomal RNA genes in each nucleolus organizer region of the two X chromosomes. When this same nucleolus organizer region is present in flies in only a single dose, the number of ribosomal RNA genes increases to approximately 400. This increase is most easily explained by disproportionate replication of these genes.

PMID: 5538845 [PubMed - indexed for MEDLINE]