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1: FEBS Lett. 1996 Mar 18;382(3):319-22.
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Pseudogenes in ribonuclease evolution: a source of new biomacromolecular function?

Trabesinger-Ruef N, Jermann T, Zankel T, Durrant B, Frank G, Benner SA.

Department of Chemistry, ETH, Zurich, Switzerland.

Bovine seminal ribonuclease (RNase) diverged from pancreatic RNase after a gene duplication ca. 35 million years ago. Members of the seminal RNase gene family evidently remained as unexpressed pseudogene for much of its evolutionary history. Between 5 and 10 million years ago, however, after the divergence of kudu but before the divergence of ox, evidence suggests that the pseudogene was repaired and expressed. Intriguingly, detailed analysis of the sequences suggests that the repair may have involved gene conversion, transfer of information from the pancreatic gene to the RNase pseudogene. Further, the ratio of non-silent to silent substitutions suggests that the pancreatic RNases are divergently evolving under functional constraints, the seminal RNase pseudogenes are diverging under no functional constraints, while the genes expressed in the seminal plasma are evolving extremely rapidly in their amino acid sequences, as if to fulfil a new physiological role.

PMID: 8605993 [PubMed - indexed for MEDLINE]