Hidden Markov models.
Eddy SR.
Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. eddy@genetics.wustl.edu
'Profiles' of protein structures and sequence alignments can detect subtle homologies. Profile analysis has been put on firmer mathematical ground by the introduction of hidden Markov model (HMM) methods. During the past year, applications of these powerful new HMM-based profiles have begun to appear in the fields of protein-structure prediction and large-scale genome-sequence analysis.
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PMID: 8804822 [PubMed - indexed for MEDLINE]