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1: Cell. 1997 Dec 26;91(7):881-91.
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Erratum in:
  • Cell 1998 Feb 20;92(4):following 585.

The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development.

Pignoni F, Hu B, Zavitz KH, Xiao J, Garrity PA, Zipursky SL.

Department of Biological Chemistry, The School of Medicine, University of California, Los Angeles 90095, USA.

Sine oculis (so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families. These genes have been proposed to act with eyeless (Pax6) to regulate eye development in vertebrates and invertebrates. so encodes a highly diverged homeobox transcription factor and eya encodes a novel nuclear protein. We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains. We propose that an So/Eya complex regulates multiple steps in eye development and functions within the context of a network of genes to specify eye tissue identity.

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PMID: 9428512 [PubMed - indexed for MEDLINE]