Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.
Pearson CE, Sinden RR.
Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University, Houston 77030-3303, USA.
Models for the disease-associated expansion of (CTG)n.(CAG)n, (CGG)n.(CCG)n, and (GAA)n.(TTC)n trinucleotide repeats involve alternative DNA structures formed during DNA replication, repair and recombination. These repeat sequences are inherently flexible and can form a variety of hairpins, intramolecular triplexes, quadruplexes, and slipped-strand structures that may be important intermediates and result in their genetic instability.
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PMID: 9666328 [PubMed - indexed for MEDLINE]