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1: Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9750-4.
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Comment in:
The nematode resistance gene Mi of tomato confers resistance against the potato aphid.

Rossi M, Goggin FL, Milligan SB, Kaloshian I, Ullman DE, Williamson VM.

Department of Nematology, University of California, Davis, CA 95616, USA.

Resistance against the aphid Macrosiphum euphorbiae previously was observed in tomato and attributed to a novel gene, designated Meu-1, tightly linked to the nematode resistance gene, Mi. Recent cloning of Mi allowed us to determine whether Meu-1 and Mi are the same gene. We show that Mi is expressed in leaves, that aphid resistance is isolate-specific, and that susceptible tomato transformed with Mi is resistant to the same aphid isolates as the original resistant lines. We conclude that Mi and Meu-1 are the same gene and that Mi mediates resistance against both aphids and nematodes, organisms belonging to different phyla. Mi is the first example of a plant resistance gene active against two such distantly related organisms. Furthermore, it is the first isolate-specific insect resistance gene to be cloned and belongs to the nucleotide-binding, leucine-rich repeat family of resistance genes.

Publication Types:
PMID: 9707547 [PubMed - indexed for MEDLINE]

PMCID: PMC21408