Biology for the post-genomic era

Fully Open Access. Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genomics of disease; and clinical genomics. All content is open access immediately on publication.


  • Louisa Flintoft PhD, Genome Biology


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  • HER2 heterogeneous cancer

    An analysis of HER2 heterogeneous breast cancers reveals an important role of the HER2 negative component of the HER2 positive tumors

    Genome Biology 2015, 16:107
  • Open science = Science

    Mick Watson ponders on why open science is simply good science, and why the notion of closed science must die

    Genome Biology 2015, 16:101
  • Partial protein domains

    Lawrence Kelley and Michael Sternberg discuss the bioinformatic challenges in studying partial protein domains, and what can we learn from them

    Genome Biology 2015, 16:100
  • Partial protein domains

    Partial protein domains are characterized, and are found to be largely alignment or annotation artifacts

    Genome Biology 2015, 16:99
  • Unique microbial identity

    Jack Gilbert discusses recent work from Peer Bork's group on the extent of the individual microbiome variation

    Genome Biology 2015, 16:97
  • HaploShare

    HaploShare is a method for identification of extended haplotypes shared by cases and for comparison against controls

    Genome Biology 2015, 16:92
  • LICHeE

    A method for fast and scalable inference of multi-sample cancer lineages

    Genome Biology 2015, 16:91
  • OGD translational response

    Novel regulatory mechanisms of translational response to oxygen and glucose deprivation in mammalian cells

    Genome Biology 2015, 16:90
  • Goose genome sequence

    The first genome sequence of the goose reveals a mechanism for the susceptibility of geese to fatty liver disease

    Genome Biology 2015, 16:89
  • Protein domain atrophy

    Systematic identification of protein domain atrophy across all known protein sequences

    Genome Biology 2015, 16:88
  • Cloning-free CRISPR/Cas system

    A new genome editing method facilitates generation of functional cassette knockin in mice

    Genome Biology 2015, 16:87
Genome Editing
3D Organisation of the nucleus
Genome Biology Single Cell
Genomics of infectious diseases: special issue
Avian Genomes collection

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ISSN: 1465-6906