Biology for the post-genomic era
Genome Biology publishes research articles, new methods and software tools, in addition to reviews and opinions, from the full spectrum of biology, including molecular, cellular, organism or population biology studied from a genomic perspective, as well as sequence analysis, bioinformatics, proteomics, comparative biology and evolution.
- Clare Garvey PhD, Genome Biology
Mark Gerstein and colleagues describe a new orthology-based framework for cross-species clustering
An analysis of the evolution of DNA copy numbers in the fruit fly
IntClust is a genome-driven breast cancer classifier which subtypes these cancers based on gene expression alone
Charles Swanton and colleagues review the ins and outs of intratumor heterogeneity and how does it affect personalized medicine
Obi Griffith, Andrew Su and colleagues discuss the challenges of combining the genomic knowledge and N-of-1 studies to improve personalized medicine
David Adams and colleagues discuss the elegant approach for the cancer evolution studies, combining sequencing with the clever choice of cancer models
An analysis of sporadic renal cell carcinoma case reveals new insights about evolutionary principles affecting tumor development
Tumor evolution in a diffuse gastric cancer patient and cancer modeling reveals the metastatic contribution of Tgfbr2 loss-of-function
A new statistical framework for the reconstruction of tumor clone structure
A new method for the analysis of the clonal hierarchy of somatic genomic aberrations from WGS and WES data
Software for the analysis and quantification of single cell heterogeneity in immunofluorescence and FISH data
Featured free review
Scott Kelley and Jack Gilbert review the microbiology of the built environment, and highlight how genomics can empower its study.
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Free webinar on plant genomics:
Breeding opportunities out of challenges, broadcast live 18th April 2013 sponsored by Affymetrix. A free to view panel discussion between Clare Garvey, Editor – Genome Biology, BioMed Central, Etienne Paux, INRA and Doreen Ware, USDA ARS, Adjunct Associate Professor, Cold Spring Harbor Laboratory.