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A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes.
Knight RD, Freeland SJ, Landweber LF.
Genome Biol. 2001;2(4):RESEARCH0010. Epub 2001 Mar 22.
PMID: 11305938 [PubMed - indexed for MEDLINE]
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