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Items 1 - 20 of 120
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1:

Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.

Lam LT, Pickeral OK, Peng AC, Rosenwald A, Hurt EM, Giltnane JM, Averett LM, Zhao H, Davis RE, Sathyamoorthy M, Wahl LM, Harris ED, Mikovits JA, Monks AP, Hollingshead MG, Sausville EA, Staudt LM.

Genome Biol. 2001;2(10):RESEARCH0041. Epub 2001 Sep 13.

PMID: 11597333 [PubMed - indexed for MEDLINE]

2:

Transcriptional signature of flavopiridol-induced tumor cell death.

Lü X, Burgan WE, Cerra MA, Chuang EY, Tsai MH, Tofilon PJ, Camphausen K.

Mol Cancer Ther. 2004 Jul;3(7):861-72.

PMID: 15252147 [PubMed - indexed for MEDLINE]

3:

Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells.

Raju U, Nakata E, Mason KA, Ang KK, Milas L.

Cancer Res. 2003 Jun 15;63(12):3263-7.

PMID: 12810657 [PubMed - indexed for MEDLINE]

5:

Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.

Senderowicz AM.

Cancer Chemother Pharmacol. 2003 Jul;52 Suppl 1:S61-73. Epub 2003 Jun 18. Review.

PMID: 12819936 [PubMed - indexed for MEDLINE]

6:

Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.

Smith V, Raynaud F, Workman P, Kelland LR.

Mol Pharmacol. 2001 Nov;60(5):885-93.

PMID: 11641415 [PubMed - indexed for MEDLINE]

7:

Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.

Wittmann S, Bali P, Donapaty S, Nimmanapalli R, Guo F, Yamaguchi H, Huang M, Jove R, Wang HG, Bhalla K.

Cancer Res. 2003 Jan 1;63(1):93-9.

PMID: 12517783 [PubMed - indexed for MEDLINE]

8:

Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.

Wu K, Wang C, D'Amico M, Lee RJ, Albanese C, Pestell RG, Mani S.

Mol Cancer Ther. 2002 Jul;1(9):695-706.

PMID: 12479366 [PubMed - indexed for MEDLINE]

9:

Mechanisms of action of flavopiridol.

Sedlacek HH.

Crit Rev Oncol Hematol. 2001 May;38(2):139-70. Review.

PMID: 11311660 [PubMed - indexed for MEDLINE]

10:

Growth inhibition and induction of apoptosis by flavopiridol in rat lung adenocarcinoma, osteosarcoma and malignant fibrous histiocytoma cell lines.

Honoki K, Yoshitani K, Tsujiuchi T, Mori T, Tsutsumi M, Morishita T, Takakura Y, Mii Y.

Oncol Rep. 2004 May;11(5):1025-30.

PMID: 15069542 [PubMed - indexed for MEDLINE]

11:

Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.

Kobayashi S, Shimamura T, Monti S, Steidl U, Hetherington CJ, Lowell AM, Golub T, Meyerson M, Tenen DG, Shapiro GI, Halmos B.

Cancer Res. 2006 Dec 1;66(23):11389-98.

PMID: 17145885 [PubMed - indexed for MEDLINE]

12:

Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity.

Newcomb EW.

Anticancer Drugs. 2004 Jun;15(5):411-9. Review.

PMID: 15166614 [PubMed - indexed for MEDLINE]

13:

Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: Implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury.

Jaschke B, Milz S, Vogeser M, Michaelis C, Vorpahl M, Schömig A, Kastrati A, Wessely R.

FASEB J. 2004 Aug;18(11):1285-7. Epub 2004 Jun 4.

PMID: 15180955 [PubMed - indexed for MEDLINE]

14:

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.

Dai Y, Rahmani M, Pei XY, Dent P, Grant S.

Blood. 2004 Jul 15;104(2):509-18. Epub 2004 Mar 23.

PMID: 15039284 [PubMed - indexed for MEDLINE]

15:

Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients.

Nakanishi T, Karp JE, Tan M, Doyle LA, Peters T, Yang W, Wei D, Ross DD.

Clin Cancer Res. 2003 Aug 15;9(9):3320-8.

PMID: 12960118 [PubMed - indexed for MEDLINE]

16:

Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase.

Matranga CB, Shapiro GI.

Cancer Res. 2002 Mar 15;62(6):1707-17.

PMID: 11912144 [PubMed - indexed for MEDLINE]

17:

Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex.

Biglione S, Byers SA, Price JP, Nguyen VT, Bensaude O, Price DH, Maury W.

Retrovirology. 2007 Jul 11;4:47.

PMID: 17625008 [PubMed - indexed for MEDLINE]

19:

Flavopiridol, an inhibitor of cyclin-dependent kinases, induces growth inhibition and apoptosis in bladder cancer cells in vitro and in vivo.

Wirger A, Perabo FG, Burgemeister S, Haase L, Schmidt DH, Doehn C, Mueller SC, Jocham D.

Anticancer Res. 2005 Nov-Dec;25(6B):4341-7.

PMID: 16309238 [PubMed - indexed for MEDLINE]

20:

Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.

Chao SH, Price DH.

J Biol Chem. 2001 Aug 24;276(34):31793-9. Epub 2001 Jun 28.

PMID: 11431468 [PubMed - indexed for MEDLINE]

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