Granzymes: a family of lymphocyte granule serine proteases.

Trapani JA.

Genome Biol. 2001;2(12):REVIEWS3014. Epub 2001 Nov 23. Review.

PMID: 11790262 [PubMed - indexed for MEDLINE]

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Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.

Smyth MJ, O'Connor MD, Trapani JA.

J Leukoc Biol. 1996 Nov;60(5):555-62. Review.

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Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.

Kam CM, Hudig D, Powers JC.

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The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes.

Edwards KM, Kam CM, Powers JC, Trapani JA.

J Biol Chem. 1999 Oct 22;274(43):30468-73.

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A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1.

Smyth MJ, O'Connor MD, Trapani JA, Kershaw MH, Brinkworth RI.

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Granule serine proteases are normal nuclear constituents of natural killer cells.

Trapani JA, Smyth MJ, Apostolidis VA, Dawson M, Browne KA.

J Biol Chem. 1994 Jul 15;269(28):18359-65.

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Hypothesis: cytotoxic lymphocyte granule serine proteases activate target cell endonucleases to trigger apoptosis.

Smyth MJ, Browne KA, Thia KY, Apostolidis VA, Kershaw MH, Trapani JA.

Clin Exp Pharmacol Physiol. 1994 Jan;21(1):67-70.

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Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3.

Chinnaiyan AM, Hanna WL, Orth K, Duan H, Poirier GG, Froelich CJ, Dixit VM.

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Bioinformatics of granzymes: sequence comparison and structural studies on granzyme family by homology modeling.

Sattar R, Ali SA, Abbasi A.

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Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates.

Rukamp BJ, Kam CM, Natarajan S, Bolton BW, Smyth MJ, Kelly JM, Powers JC.

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Synthesis and kinetic studies of diphenyl 1-(N-peptidylamino)alkanephosphonate esters and their biotinylated derivatives as inhibitors of serine proteases and probes for lymphocyte granzymes.

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Arch Biochem Biophys. 1997 Aug 15;344(2):271-80.

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Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation.

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Generation of antigenic peptides by lymphocyte granule serine proteases (granzymes).

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Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

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Characterization, application and potential uses of biotin-tagged inhibitors for lymphocyte serine proteases (granzymes).

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The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity.

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