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Housekeeping genes tend to show reduced upstream sequence conservation.
Farré D, Bellora N, Mularoni L, Messeguer X, Albà MM.
Genome Biol. 2007;8(7):R140.
PMID: 17626644 [PubMed - indexed for MEDLINE]
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Genes involved in complex adaptive processes tend to have highly conserved upstream regions in mammalian genomes.
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Position and distance specificity are important determinants of cis-regulatory motifs in addition to evolutionary conservation.
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