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1:

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype.

Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS.

Genome Biol. 2008;9(6):R100. Epub 2008 Jun 20.

PMID: 18570634 [PubMed - indexed for MEDLINE]

2:

Acute hepatotoxicity: a predictive model based on focused illumina microarrays.

Zidek N, Hellmann J, Kramer PJ, Hewitt PG.

Toxicol Sci. 2007 Sep;99(1):289-302. Epub 2007 May 22.

PMID: 17522070 [PubMed - indexed for MEDLINE]

3:

Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice.

Boverhof DR, Burgoon LD, Tashiro C, Sharratt B, Chittim B, Harkema JR, Mendrick DL, Zacharewski TR.

Toxicol Sci. 2006 Dec;94(2):398-416. Epub 2006 Sep 7.

PMID: 16960034 [PubMed - indexed for MEDLINE]

4:

Discriminating different classes of toxicants by transcript profiling.

Steiner G, Suter L, Boess F, Gasser R, de Vera MC, Albertini S, Ruepp S.

Environ Health Perspect. 2004 Aug;112(12):1236-48.

PMID: 15345370 [PubMed - indexed for MEDLINE]

5:

Correlation of simultaneous differential gene expression in the blood and heart with known mechanisms of adriamycin-induced cardiomyopathy in the rat.

Brown HR, Ni H, Benavides G, Yoon L, Hyder K, Giridhar J, Gardner G, Tyler RD, Morgan KT.

Toxicol Pathol. 2002 Jul-Aug;30(4):452-69.

PMID: 12187937 [PubMed - indexed for MEDLINE]

6:

Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories.

Boedigheimer MJ, Wolfinger RD, Bass MB, Bushel PR, Chou JW, Cooper M, Corton JC, Fostel J, Hester S, Lee JS, Liu F, Liu J, Qian HR, Quackenbush J, Pettit S, Thompson KL.

BMC Genomics. 2008 Jun 12;9:285.

PMID: 18549499 [PubMed - indexed for MEDLINE]

7:

Development of an approach for ab initio estimation of compound-induced liver injury based on global gene transcriptional profiles.

Dai X, He YD, Dai H, Lum PY, Roberts CJ, Waring JF, Ulrich RG.

Genome Inform. 2006;17(2):77-88.

PMID: 17503381 [PubMed - indexed for MEDLINE]

8:

Benzene metabolism in rodents at doses relevant to human exposure from urban air.

Turteltaub KW, Mani C.

Res Rep Health Eff Inst. 2003 Feb;(113):1-26; discussion 27-35.

PMID: 12675491 [PubMed - indexed for MEDLINE]

9:

Literature-based compound profiling: application to toxicogenomics.

Frijters R, Verhoeven S, Alkema W, van Schaik R, Polman J.

Pharmacogenomics. 2007 Nov;8(11):1521-34.

PMID: 18034617 [PubMed - indexed for MEDLINE]

10:

Gene expression profiling in rat liver treated with compounds inducing phospholipidosis.

Hirode M, Ono A, Miyagishima T, Nagao T, Ohno Y, Urushidani T.

Toxicol Appl Pharmacol. 2008 Jun 15;229(3):290-9. Epub 2008 Feb 14.

PMID: 18355885 [PubMed - indexed for MEDLINE]

11:

NTP Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

National Toxicology Program.

Natl Toxicol Program Tech Rep Ser. 1993 Sep;422:1-340.

PMID: 12616289 [PubMed - as supplied by publisher]

12:

Validation of putative genomic biomarkers of nephrotoxicity in rats.

Wang EJ, Snyder RD, Fielden MR, Smith RJ, Gu YZ.

Toxicology. 2008 Apr 18;246(2-3):91-100. Epub 2008 Jan 16.

PMID: 18289764 [PubMed - indexed for MEDLINE]

13:

Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations.

Heinloth AN, Boorman GA, Foley JF, Flagler ND, Paules RS.

Toxicol Pathol. 2007;35(2):276-83. Erratum in: Toxicol Pathol. 2007;35(6):850.

PMID: 17366322 [PubMed - indexed for MEDLINE]

14:

Characteristic expression profiles induced by genotoxic carcinogens in rat liver.

Ellinger-Ziegelbauer H, Stuart B, Wahle B, Bomann W, Ahr HJ.

Toxicol Sci. 2004 Jan;77(1):19-34. Epub 2003 Nov 4.

PMID: 14600272 [PubMed - indexed for MEDLINE]

15:

Gene expression profiling of rat livers reveals indicators of potential adverse effects.

Heinloth AN, Irwin RD, Boorman GA, Nettesheim P, Fannin RD, Sieber SO, Snell ML, Tucker CJ, Li L, Travlos GS, Vansant G, Blackshear PE, Tennant RW, Cunningham ML, Paules RS.

Toxicol Sci. 2004 Jul;80(1):193-202. Epub 2004 Apr 14.

PMID: 15084756 [PubMed - indexed for MEDLINE]

16:

D-Serine exposure resulted in gene expression changes indicative of activation of fibrogenic pathways and down-regulation of energy metabolism and oxidative stress response.

Soto A, DelRaso NJ, Schlager JJ, Chan VT.

Toxicology. 2008 Jan 14;243(1-2):177-92. Epub 2007 Oct 23.

PMID: 18061331 [PubMed - indexed for MEDLINE]

17:

Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers.

Thukral SK, Nordone PJ, Hu R, Sullivan L, Galambos E, Fitzpatrick VD, Healy L, Bass MB, Cosenza ME, Afshari CA.

Toxicol Pathol. 2005;33(3):343-55.

PMID: 15805072 [PubMed - indexed for MEDLINE]

18:

Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue.

Auman JT, Chou J, Gerrish K, Huang Q, Jayadev S, Blanchard K, Paules RS.

Environ Health Perspect. 2007 Apr;115(4):572-8. Epub 2007 Jan 17.

PMID: 17450226 [PubMed - indexed for MEDLINE]

19:

RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays.

Bulera SJ, Eddy SM, Ferguson E, Jatkoe TA, Reindel JF, Bleavins MR, De La Iglesia FA.

Hepatology. 2001 May;33(5):1239-58.

PMID: 11343254 [PubMed - indexed for MEDLINE]

20:

Application of visualization tools to the analysis of histopathological data enhances biological insight and interpretation.

Lobenhofer EK, Boorman GA, Phillips KL, Heinloth AN, Malarkey DE, Blackshear PE, Houle C, Hurban P.

Toxicol Pathol. 2006;34(7):921-8.

PMID: 17178692 [PubMed - indexed for MEDLINE]

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