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.refereed research


Genome Biology aims to provide the best possible service to authors and readers of primary research articles. The refereed research section publishes peer-reviewed research in all areas of molecular, cellular, organismal and population biology that are informed by genomics. All research articles are made available free to individuals through the web, and there are no restrictions on article length or on the types of information that can be included. The publication schedule is very fast, using electronic systems for article delivery, proofing and peer-review. For more details about how refereed research is published in Genome Biology and for instructions for authors, see 'about refereed research'.
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Refereed research
The editor's selection of the most interesting refereed research published recently in Genome Biology.

Conserved developmental transcriptomes in evolutionary divergent species

Research    
Anup Parikh, Edward Roshan Miranda, Mariko Katoh-Kurasawa, Danny Fuller, Gregor Rot, Lan Zagar, Tomaz Curk, Richard Sucgang, Rui Chen, Blaz Zupan, William F Loomis, Adam Kuspa, Gad Shaulsky
(17 March 2010)

Transcriptional profiling of Dictyostelium development reveals significant conservation of transcriptional profiles between evolutionarily divergent species.

[Abstract] [Provisional PDF]

Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells

Research    
Thomas K Albert, Krobinian Grote, Stefan Boeing, Michael Meisterernst
(15 March 2010)

Genome-wide mapping of the human TFIIB and NC2 transcription factor binding sites reveals insights into the formation of the pre-initiation complex.

[Abstract] [Provisional PDF]

Comparative genomics reveals 104 candidate structured RNAs from bacteria, archaea and their metagenomes

Research    
Zasha Weinberg, Joy X Wang, Jarrod Bogue, Jingying Yang, Keith Corbino, Ryan H Moy, Ronald R Breaker
(15 March 2010)

Novel motifs identified in a comparative genomic analysis of bacterial, archaeal and metagenomic data reveals over 100 candidate structured RNAs.

[Abstract] [Provisional PDF]

Genome-wide functional analysis of human 5'untranslated region introns

Research    
Can Cenik, Adnan Derti, Joseph C Mellor, Gabriel F Berriz, Frederick P Roth
(11 March 2010)

Genes with short 5UTR introns have higher expression than genes with no or long 5UTR introns. Complex evolutionary forces act on these introns.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates

Research    
Zhengdong D Zhang, Adam Frankish, Toby Hunt, Jennifer Harrow, Mark Gerstein
(8 March 2010)

Novel human pseudogenes are identified that had previous functionality and their age is estimated. The rate of loss-of-function occurred uniformly.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

High-resolution transcription atlas of the mitotic cell cycle in budding yeast

Research    
Marina V Granovskaia, Lars J Jensen, Matthew E Ritchie, Joern Toedling, Ye Ning, Peer Bork, Wolfgang Huber, Lars M Steinmetz
(1 March 2010)

A high resolution strand-specific transcriptional atlas of the budding yeast mitotic cell cycle, including both mRNA and non-coding RNA profiles.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Immunity and other defenses in pea aphids, Acyrthosiphon pisum

Research    
Nicole M Gerardo, Boran Altincicek, Caroline Anselme, Hagop Atamian, Seth M Barribeau, Martin de Vos, Elizabeth J Duncan, Jay D Evans, Toni Gabaldón, Murad Ghanim, Adelaziz Heddi, Isgouhi Kaloshian, Amparo Latorre, Andres Moya, Atsushi Nakabachi, Benjamin J Parker, Vincente Pérez-Brocal, Miguel Pignatelli, Yvan Rahbé, John S Ramsey, et al.
(23 February 2010)

The genome of the pea aphid Acyrthosiphon pisum lacks genes thought to be crucial in other insects for recognition, signaling and killing of microbes.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Genomic features defining exonic variants that modulate splicing

Research    
Adam Woolfe, James C Mullikin, Laura Elnitski
(16 February 2010)

A comparative analysis of SNPs and their exonic and intronic environments identifies the features predictive of splice affecting variants.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Additional refereed research articles from Genome Biology. For a complete listing choose 'list all' from the menu to the left.





























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