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.refereed research


Genome Biology aims to provide the best possible service to authors and readers of primary research articles. The refereed research section publishes peer-reviewed research in all areas of molecular, cellular, organismal and population biology that are informed by genomics. All research articles are made available free to individuals through the web, and there are no restrictions on article length or on the types of information that can be included. The publication schedule is very fast, using electronic systems for article delivery, proofing and peer-review. For more details about how refereed research is published in Genome Biology and for instructions for authors, see 'about refereed research'.

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Refereed research

2X genomes - depth does matter

Research    
Michel C Milinkovitch, Raphael Helaers, Eric Depiereux, Athanasia C Tzika, Toni Gabaldon
(9 February 2010)

The use of low coverage genomes in comparative evolutionary analyses to determine gene gain and loss events skews genome estimates.

[Abstract] [Provisional PDF]

A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454

Method    
Niall J Lennon, Robert E Lintner, Scott Anderson, Pablo Alvarez, Andrew Barry, William Brockman, Riza Daza, Rachel Erlich, Georgia Giannoukos, Lisa Green, Andrew Hollinger, Cindi A Hoover, David B Jaffe, Frank Juhn, Danielle McCarthy, Danielle Perrin, Karen Ponchner, Taryn L Powers, Kamran Rizzolo, Dana Robbins, Elizabeth Ryan, Carsten Russ, Todd Sparrow, John Stalker, Scott Steelman, Michael Weiand, Andrew Zimmer, Matthew R Henn, Chad Nusbaum, Robert Nicol
(5 February 2010)

An automated method for constructing libraries for 454 sequencing significantly reduces the cost and time required.

[Abstract] [Provisional PDF]

Genomic and small RNA sequencing of Miscanthus x giganteus shows the utility of sorghum as a reference genome sequence for Andropogoneae grasses

Research    
Kankshita Swaminathan, Magdy Alabady, Kranthi Varala, Emanuele De Paoli, Isaac Ho, Dan S Rokhsar, Aru K Arumuganathan, Ray Ming, Pamela J Green, Blake C Meyers, Stephen P Moose, Matthew E Hudson
(3 February 2010)

Genomic data together with sequencing of tissue specific small RNA libraries reveals insights into the genome content, small RNA repertoire and evolutionary origins of the grass Miscanthus x giganteus.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Gene ontology analysis for RNA-seq: accounting for selection bias

Method    
Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack
(4 February 2010)

GOseq is a method for Gene Ontology analysis of RNA-seq data that takes into account the length bias inherent in RNA-seq.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Characterization of X-Linked SNP genotypic variation in globally-distributed human populations

Research    
Amanda M Casto, Jun Z Li, Devin Absher, Richard Myers, Sohini Ramachandran, Marcus W Feldman
(28 January 2010)

An analysis of X-linked genetic variation in human populations provides insights into population structure and demographic patterns.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging

Method    
Kristen Fortney, Max Kotlyar, Igor Jurisica
(3 February 2010)

An algorithm for determining networks from gene expression data enables the identification of genes potentially linked to aging in worms.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats

Research    
Tiebing Liang, Mark W Kimpel, Jeanette N McClintick, Ashley R Skillman, Kevin McCall, Howard J Edenberg, Lucinda G Carr
(3 February 2010)

Transcriptional profiling of specific regions of inbred rat brains reveals genes associated with alcohol preference in a known QTL locus on chromosome 4

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data

Method    
Manuela Marullo, Chiara Zuccato, Caterina Mariotti, Nayana Lahiri, Sarah J Tabrizi, Stefano Di Donato, Elena Cattaneo
(28 January 2010)

Expressed Alu repeats are a reliable, accurate and universal reference for use in RT-qPCR normalization of human genes

[Abstract] [Provisional PDF] [PubMed] [Related articles]



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