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.refereed research


Genome Biology aims to provide the best possible service to authors and readers of primary research articles. The refereed research section publishes peer-reviewed research in all areas of molecular, cellular, organismal and population biology that are informed by genomics. All research articles are made available free to individuals through the web, and there are no restrictions on article length or on the types of information that can be included. The publication schedule is very fast, using electronic systems for article delivery, proofing and peer-review. For more details about how refereed research is published in Genome Biology and for instructions for authors, see 'about refereed research'.

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Refereed research

The genome sequence of the model ascomycete fungus Podospora anserina

Research    
Eric Espagne, Olivier Lespinet, Fabienne Malagnac, Corinne Da Silva, Olivier Jaillon, Betina M Porcel, Arnaud Couloux, Jean-Marc Aury, Béatrice Ségurens, Julie Poulain, Véronique Anthouard, Sandrine Grossetete, Hamid Khalili, Evelyne Coppin, Michelle Déquard-Chablat, Marguerite Picard, Véronique Contamine, Sylvie Arnaise, Anne Bourdais, Véronique Berteaux-Lecellier, Daniel Gautheret, Ronald P de Vries, Evy Battaglia, Pedro M Coutinho, Etienne GJ Danchin, Bernard Henrissat, Riyad EL Khoury, Annie Sainsard-Chanet, Antoine Boivin, Bérangère Pinan-Lucarré, Carole H Sellem, Robert Debuchy, Patrick Wincker, Jean Weissenbach, Philippe Silar
(6 May 2008)

A 10X draft sequence of Podospora anserina genome shows highly dynamic evolution since its divergence from Neurospora crassa.

[Abstract] [Full text] [PDF]

ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues?

Method    
Peter Van Loo, Stein Aerts, Bernard Thienpont, Bart De Moor, Yves Moreau, Peter Marynen
(7 April 2008)

ModuleMiner detects cis-regulatory modules in a set of co-expressed genes in tissue-specific microarray clusters and in embryonic development datasets.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Widespread duplications in the genomes of laboratory stocks of Dictyostelium discoideum

Research    
Gareth Bloomfield, Yoshimasa Tanaka, Jason Skelton, Alasdair Ivens, Robert R Kay
(22 April 2008)

Comparative genome hybridization in 38 widely used laboratory strains of the social amoeba Dictyostelium discoideum detects previously unreported duplications and deletions in the Dictyostelium genome and highlights genetic variability between strains.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Evolutionary potentials: structure specific knowledge-based potentials exploiting the evolutionary record of sequence homologs

Method    
Alejandro Panjkovich, Francisco Melo, Marc A Marti-Renom
(8 April 2008)

So-called Evolutionary potentials for protein structure prediction are derived using a single experimental protein structure and all three-dimensional models of its homologous sequences.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways

Research    
Irmgard U Haussmann, Kalpana White, Matthias Soller
(17 April 2008)

The neuronally expressed transcription factor gene ewg is shown to be a major target of the RNA-binding protein ELAV. EWG restricts synaptic growth at neuromuscular junctionsby integrating multiple signal pathways.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage

Method    
Robin Ketteler, Zairen Sun, Karl F Kovacs, Wei-Wu He, Brian Seed
(3 April 2008)

A new system based on non-conventional secretion of the luciferase from Gaussia princeps (GLUC) can be used to detect intracellular proteolysis in vivo.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling

Research    
Chandran Vijayendran, Aiko Barsch, Karl Friehs, Karsten Niehaus, Anke Becker, Erwin Flaschel
(10 April 2008)

Transcript and metabolite abundance changes were analyzed in evolved and ancestor strains of Escherichia coli in three different evolutionary conditions

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes

Research    
Sandip Paul, Sumit K Bag, Sabyasachi Das, Eric T Harvill, Chitra Dutta
(9 April 2008)

A comparative genomic and proteomic study of halophilic and non-halophilic prokaryotes identifies specific genomic and proteomic features typical of halophilic species that are independent from genomic GC-content and taxonomic position.

[Abstract] [Provisional PDF] [PubMed] [Related articles]



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