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.refereed research


Genome Biology aims to provide the best possible service to authors and readers of primary research articles. The refereed research section publishes peer-reviewed research in all areas of molecular, cellular, organismal and population biology that are informed by genomics. All research articles are made available free to individuals through the web, and there are no restrictions on article length or on the types of information that can be included. The publication schedule is very fast, using electronic systems for article delivery, proofing and peer-review. For more details about how refereed research is published in Genome Biology and for instructions for authors, see 'about refereed research'.

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Refereed research

Genomic linkage map of the human blood fluke Schistosoma mansoni

Research    
Charles D Criscione, Claudia LL Valentim, Hirohisa Hirai, Philip T LoVerde, Timothy JC Anderson
(30 June 2009)

The first genetic linkage map of Schistosoma mansoni reveals insights into higher female recombination, confirms ZW inheritance patterns and recombination hotspots.

[Abstract] [Provisional PDF]

Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea

Research    
Yvan Zivanovic, Jean Armengaud, Arnaud Lagorce, Christophe Leplat, Philippe Guerin, Murielle Dutertre, Veronique Anthouard, Patrick Forterre, Patrick Wincker, Fabrice Confalonieri
(26 June 2009)

The genome sequence of Thermococcus gammatolerans, a radioresistant archaeon, is described; a proteomic analysis reveals that radioresistance may be due to unknown DNA repair enzymes.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

A novel and universal method for microRNA RT-qPCR data normalization

Method    
Pieter Mestdagh, Pieter Van Vlierberghe, An De Weer, Daniel Muth, Frank Westermann, Frank Speleman, Jo Vandesompele
(16 June 2009)

The mean expression value: a new method for accurate and reliable normalization of microRNA expression data from RT-qPCR experiments.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Global expression analysis of the brown alga Ectocarpus siliculosus (Phaeophyceae) reveals large-scale reprogramming of the transcriptome in response to abiotic stress

Research    
Simon M Dittami, Delphine Scornet, Jean-Louis Petit, Beatrice Segurens, Corinne Da Silva, Erwan Corre, Michael Dondrup, Karl-Heinz Glatting, Rainer Konig, Lieven Sterck, Pierre Rouze, Yves Van de Peer, J Mark Cock, Catherine Boyen, Thierry Tonon
(16 June 2009)

The brown alga Ectocarpus siliculosus, unlike terrestrial plants, undergoes extensive reprogramming of its transcriptome during the acclimation to mild abiotic stress.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons

Research    
Rui Liu, Sridhar Hannenhalli, Maja Bucan
(1 July 2009)

An integrative strategy of comparative genomics, experimental and computational approaches reveals aspects of a regulatory network controlling neuronal-specific expression in presynaptic neurons.

[Abstract] [Provisional PDF]

Closing gaps in the human genome using sequencing by synthesis

Method    
Manuel Garber, Michael C Zody, Harindra M Arachchi, Aaron Berlin, Sante Gnerre, Lisa M Green, Niall Lennon, Chad Nusbaum
(2 June 2009)

A novel method for closing non-structural gaps in the human genome assembly using 454 sequencing is presented here.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

The conservation and evolutionary modularity of metabolism

Research    
Jose M Peregrin-Alvarez, Chris Sanford, John Parkinson
(12 June 2009)

A novel evolutionary analysis of metabolic networks across 26 taxa reveals a highly-conserved but flexible core of metabolic enzymes.

[Abstract] [Provisional PDF] [PubMed] [Related articles]

Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana

Research    
Xiaoyu Zhang, Yana V Bernatavichute, Shawn Cokus, Matteo Pellegrini, Steven E Jacobsen
(9 June 2009)

Analysis of the genome-wide distribution patterns of histone H3 lysine4 methylation in Arabidopsis thaliana seedlings shows that it has widespread roles in regulating gene expression.

[Abstract] [Provisional PDF] [PubMed] [Related articles]



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