Genome Biology aims to provide review material that readers need in order to assess and evaluate progress in genomic and post-genomic research. Reviews include systematic and substantial coverage of mature subjects, rapid coverage of fast-moving areas, evaluations of progress in specified areas, and critical assessments of emerging technologies. Reviews are usually commissioned, with the editors aiming to ensure coverage of all relevant areas of biology and genomics but suggestions of reviews are welcome.

Review   

(2 May 2008)

Promoter-proximal polymerase II stalling prepares genes for prompt expression when signals are received.

Review   

(30 April 2008)

The AAA+ superfamily is a large superfamily of ATPases that are characterized by a conserved catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes.

Review   

(24 April 2008)

New techniques are enabling the identification of genetic variants underlying complex diseases and phenotypic traits.

Review   

(10 March 2008)

A variety of innate immune system receptors recognize and respond to the nucleic acids of invading pathogens.

Review   

(18 February 2008)

Recent studies of genomic DNA from Neanderthal fossils support earlier studies showing no contribution of Neanderthals to the gene pool of modern humans.

Review   

(22 January 2008)

Specific attachment of chromosomal sites to the nuclear matrix is crucial to the control of transcription and DNA replication.

Review   

(28 December 2007)

Supplementing metagenomic approaches to studying natural microbial communities with metatranscriptomics and metaproteomics should reap big dividends

Review   

(23 November 2007)

Cellular defence mechanisms against HIV contribute to its persistence.