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Genome Biology aims to provide review material that readers need in order to assess and evaluate progress in genomic and post-genomic research. Reviews include systematic and substantial coverage of mature subjects, rapid coverage of fast-moving areas, evaluations of progress in specified areas, and critical assessments of emerging technologies. Reviews are usually commissioned, with the editors aiming to ensure coverage of all relevant areas of biology and genomics but suggestions of reviews are welcome.
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Reviews

Translational disease interpretation with molecular networks

Review   
Anaïs Baudot, Gonzalo Gómez-López, Alfonso Valencia
(29 June 2009)

The integration of medical information into gene and protein networks could lead to a better understanding of complex diseases.

[Abstract] [Full text] [PDF]

Learning to get along despite struggling to get by

Review   
Elizabeth A Ostrowski, Gad Shaulsky
(26 May 2009)

A review of evolutionary theories for cooperation, with emphasis on the mechanisms that can favor cooperation and reduce conflict within multicellular organisms, enabling the transition from unicellular to multicellular life.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Protein function annotation by homology-based inference

Review   
Yaniv Loewenstein, Domenico Raimondo, Oliver C Redfern, James Watson, Dmitrij Frishman, Michal Linial, Christine Orengo, Janet Thornton, Anna Tramontano
(2 February 2009)

Where information on homologous proteins is available, progress is being made in automated prediction of protein function from sequence and structure.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Sequence-based feature prediction and annotation of proteins

Review   
Agnieszka S Juncker, Lars J Jensen, Andrea Pierleoni, Andreas Bernsel, Michael L Tress, Peer Bork, Gunnar von Heijne, Alfonso Valencia, Christos A Ouzounis, Rita Casadio, Søren Brunak
(2 February 2009)

The combination of prediction tools in complex workflows and pipelines facilitates prediction of protein features from sequence.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Identifying protein-coding genes in genomic sequences

Review   
Jennifer Harrow, Alinda Nagy, Alexandre Reymond, Tyler Alioto, Laszlo Patthy, Stylianos E Antonarakis, Roderic Guigó
(30 January 2009)

A review of the main computational pipelines used to generate the human reference protein-coding gene sets.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Integrating sequence, evolution and functional genomics in regulatory genomics

Review   
Martin Vingron, Alvis Brazma, Richard Coulson, Jacques van Helden, Thomas Manke, Kimmo Palin, Olivier Sand, Esko Ukkonen
(30 January 2009)

Finding transcription factor binding sites in regulatory regions of the genome

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Next-generation biomass feedstocks for biofuel production

Review   
Blake A Simmons, Dominique Loque, Harvey W Blanch
(29 December 2008)

A review of the potential for biofuel production in the United States from timber and non-grain crops.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

The telosome/shelterin complex and its functions

Review   
Huawei Xin, Dan Liu, Zhou Songyang
(18 September 2008)

The telosome/shelterin protein complex bound to telomeres is essential for maintenance of telomere structure and telomere signaling functions.

[Abstract] [Full text] [PDF] [PubMed] [Related articles]

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